Cerasomes, liposomal membranes covered with ceramic surface, were prepared from double-chain organoalkoxysilane lipids with a hydrogen-bonding unit by using ethanol sol injection method. The Cerasomes thus prepared were characterized by means of various physical measurements such as scanning and transmission electron microscopy, light scattering and differential scanning calorimetry. As compared with liposomes formed with a lipid having a quaternary ammonium head in place of the inorganic moiety, the Cerasomes were more stable to maintain their vesicular structures even in the presence of excessive amounts of a surfactant, in which the conventional liposomes were completely dissolved. Potential of the Cerasome as an organic-inorganic hybrid material for nano-device fabrications were discussed.