Carbocationic species (High Energy Intermediates) have been postulated as intermediates in the course of enzymatic synthesis of ergosterol. Protonated aza-analogues of the sterol are thus potential inhibitors. The synthesis of substituted quinolizidines (3) is reported. 4-Methoxy-2,3-dimethylpyridine (4) was metalated and reacted with substituted 3-chloropropanal to build the 1-methyl-2-quinolizidinone. The lateral chain was prepared via a Wittig-Horner reaction.