Late Cretaceous (~106–76Ma) adakite-like intrusive rocks in the middle-eastern Gangdese belt occur in an E–W trending belt paralleling the Indus–Yarlung suture, south Tibet. Their petrogenesis and geodynamic processes have been a subject of debate. We report here U–Pb zircon ages, geochemical and Sr–Nd–Hf isotopic data for adakite-like intrusive rocks as well as the normal arc rocks (gabbros and gabbroic diorites) in the middle Gangdese belt. LA-ICPMS U–Pb zircon analyses yielded an identical age of ~88Ma for two adakite-like rocks, which are slightly younger than the gabbro and gabbroic diorite (ca. 94–90Ma). Both the adakite-like rocks and the normal arc rocks have similar whole-rock Sr–Nd and zircon Hf isotope compositions, indicating that they have been derived from a common source. Similarly, the adakite-like and normal arc intrusive rocks in the eastern Gangdese belt also show similar Sr–Nd–Hf isotope compositions. In the middle-eastern Gangdese belt, the >85Ma Late Cretaceous intrusive rocks consist of a magma series from gabbro to granodiorite, including both normal arc rocks and adakite-like rocks. These rocks overlap in space and time that conform to a normal arc differentiation trend. In terms of major and trace elements, they also show a clear evolution from the normal arc magmatic into adakitic field. Thus, we suggest that these >85Ma Late Cretaceous intrusive rocks were ultimately derived from melting of the hydrated mantle wedge and the adakite-like rocks can be generated in normal arc magmas by amphibole-dominated fractionation. Taking into accounting for the spatial and temporal distribution of the Cretaceous magmatic rocks in the Lhasa terrane, we prefer a model of early Late Cretaceous rollback following Early Cretaceous low-angle oceanic slab subduction. At intermediate pressure and H2O-rich conditions, fractionation of amphibole changes the major and trace element compositions of arc magmas, and will efficiently drives basaltic composition to andesitic composition in arc magmas.