In many biomedical studies, the density of a biological system is of great importance to investigate its structure or functioning. In the present work, for the density measurement of lung phantom, the scattering of 59.54 and 662keV gamma photons are studied using HPGe and NaI(Tl) detectors, respectively. Phantoms simulating lung density are prepared by mixing appropriate amount of saw dust and distilled water. The regression lines, obtained from experimental data of scattered spectra, provide the amount of excessive water storage in lungs, hence the technique has the potential for a measure of pathological state like pulmonary edema. The technique is quite sensitive for small change (∼23Kgm −3 ) in the density of lung phantom. Also, Compton scatter profile measurements (in case of 59.54keV) results that the technique is less sensitive beyond chest wall thickness of ∼26mm due to overlying scatter components in the measured spectrum. A portable non-invasive system described presently may be used for various industrial applications also.