Sebei gas field is featured with the characteristics of the shallow-buried gas reservoir, long gas containing well ection, multilayer gas reservoirs beds, the complicated gas/water contact distribution, the water produced obviously, sands produced frequently from the gas wells and the multi-layers gas reservoir extracted unbalancedly in the developing process. For these reasons, the paper proposed the method that interlayer interference coefficients are defined with statistical function. Combined with the data of the sand-layer's profile test, the effects of the numbers of different sand-lays, the perforated thickness, the perforated interval length and permeability contrast on the interlayer interference are evaluated and these permeability parameters are optimized.