The formation of titania powders by oxidation of TiCl 4 was studied in a laminar diffusion flame reactor. The effects of flame configuration (fuel and oxidant flow rate and position) as well as precursor TiCl 4 loading on the specific surface area and phase composition of the product titania powder were investigated. Specifically, the specific surface increased from 15 to 120 m 2 /g and the rutile fraction was reduced from 15 to 0.1 wt.% by exchanging the position of the fuel and oxidant streams in the burner. Increasing the flame temperature increased the rutile fraction and the average primary particle size. Increasing the precursor TiCl 4 concentration reduced the specific surface area, especially at low TiCl 4 loadings and flame temperatures. However, it had no effect on the phase composition of the titania particles.