The “Burn-out” syndrome is a kind of labour stress produced in professions that require constant and direct relationship with other people. Health professionals, and particularly especial-care services such as Oncology, live under stressful labour conditions linked to the great responsability that goes with their job. The emotional attachment with the patient, which may be in grave conditions and could even die, or a professional care which may not bring about improvement for the patient, represent a source of burn-out for many professionals resulting in psychopathological symptomatology.If we know the triggers and sources of burnout, we can find several coping strategies that facilitate the management of stress in health professionals.Managing stress entails being aware and handling the various factors that intervene in the relationship of the professional with people and the social and labour environments.The control of the patient, professional and contextual factors is of paramount importance in order to avoid the direct consequences of the burn-out of health professionals and health institutions themselves. This control over the factors which trigger off the burn-out will provide the preventive aspect that an advanced society pursues for the improvement of health and quality of life.The burn-out is an inappropriate confrontation or a failure of the adjustment responses to the demands that exceed the capacity of the individual. This syndrome give rises to negative attitudes towards work, life and people.