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Optically active nitrogen ligands in asymmetric catalysis. Effect of nitrogen substitution on the enantioselective hydride transfer reduction of acetophenone
Both theoretical calculations and experimental data have shown that only one diamine ligand was necessary for the Rh catalytic enantioselective hydride transfer reduction of acetophenone. A mechanism is proposed. Different aza ligands were also tested in the same reaction, using rhodium, ruthenium and iridium precursors. The structure-activity-selectivity relationship of the aza ligands is discussed.