This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).This article has been retracted at the request of the Editor-in-Chief due to duplication of a Western immunoblot, published as the beta-actin band in Figure 1B, which appears in these other previously published articles:• Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats: https://doi.org/10.2337/db05-1622• Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats: https://dx.doi.org/10.1016/j.febslet.2006.08.004• Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action: https://dx.doi.org/10.1096/fj.06-7148com• A Central Role for Neuronal Adenosine 5'-Monophosphate-Activated Protein Kinase in Cancer-Induced Anorexia: https://doi.org/10.1210/en.2007-0381• A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss: https://dx.doi.org/10.2337/db07-0573• Central exercise action increases the AMPK and mTOR response to leptin: https://dx.doi.org/10.1371/journal.pone.0003856• Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats: https://dx.doi.org/10.1113/jphysiol.2008.164202• Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis: https://dx.doi.org/10.1186/cc11478• Obesity-induced increase in tumor necrosis factor-a leads to development of colon cancer in mice: https://dx.doi.org/10.1053/j.gastro.2012.05.045As the Editors investigated these problems and sought answers from the corresponding author, a corrigendum was initially published for this article (http://dx.doi.org/10.1016/j.lfs.2016.03.050), which also contains another duplicated actin blot in Figure 1C, which appears to be a duplication of Figure 2B in DeSouza et al., FASEB J 2007; Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action (https://dx.doi.org/10.1096/fj.06-7148com).