This research explores if some polymorphisms associated to Serotonin (5-HTTLPR and 5-HTTVNTR), Dopamine (DRD2), testosterone (CAG and GGN) and two enzymes (COMT [Val158Met] and MAO-A) may be linked to differences on Impulsive-Sensation Seeking, Neuroticism and Extroversion factors of the Zuckerman’s personality model. Hypothesis reproduce the concrete paths raised by Zuckerman’s Psychobiological model (Zuckerman, 2005) from differences on serotonin, dopamine, testosterone, COMT and MAO-A to differences on personality basic traits. Several phenotypic personality measures (ImpSS, N-Anx, and Sy from the ZKPQ, P from EPQ-R, Barratt’s Impulsivity Scale, and N, E, and C from the NEO-FFI) were applied to two samples: 153 inmates and 105 controls. All males. Results give some support to the Zuckerman’s psychobiological model since phenotypic differences were mostly in the predicted direction when the role of different polymorphisms was considered conjointly.