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Several protein supramolecular systems have been assembled for processing molecular information through intramolecular transfer of conformational change on the model of the biomolecular information network in biological systems. Intermolecular conformation transfer systems consist of calmodulin and phosphodiesterase. Calmodulin selectively binds calcium ions with a resulting change in its conformation that causes phosphodiesterase to change its conformation on being activated. Intermolecular transfer of conformational change has been successfully performed in response to the calcium ion by three different supramolecular systems: (1) calmodulin covalently conjugated with phosphodiesterase and immobilized on solid matrix; (2) lipid-conjugated calmodulin of monolayer on the water surface and coupled with phosphodiesterase in solution and (3) genetically engineered calmodulin self-assembled on a solid matrix and coupled with phosphodiesterase in solution. These supramolecular systems were found to be responsive to such environmental conditions as calcium ion concentration in the reversible alteration of enzyme activity.