Regulation of intracellular calcium ion concentration ([Ca 2+ ] in ) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca 2+ influx via voltage-gated Ca 2+ channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca 2+ ] in dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca 2+ ] in predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca 2+ response but also a quantitative way to regulate the [Ca 2+ ] in dynamics by controlling the external electrical stimulation.