Hypertrophic myocardiopathy is a genetic sarcomeric disease. Its severity is related to the risk of ventricular arrhythmias and sudden death. The application of a new echocardiographic tool, the 2D Strain, is being evaluated. The aims of our study were to investigate the global longitudinal Strain (GLS); Radial Strain (SR); Circumferential Strain (SC) of the left ventricle (LV) and the Longitudinal Strain (SL) of the right ventricle (RV) and to determine the value of these new parameters in the evaluation of the prognostic.It's a prospective study of 105 patients with HCM. The conventional echocardiographic parameters, GLS, SR, SC and SL RV were studied. These data were compared to the measured parameters in 65 healthy subjects matched for age and sex.The mean age was 49,3±16,7 years with a male predominance (71,2%). The mean LV ejection fraction was 60,0±4.3%. The 2D Strain study revealed a significant decrease in all components of LV myocardial deformation in patients compared to controls. The GLS was –13,8±6,2% in CMH patients Vs –21,9±1,4% in controls (p<0,01); SR was 22,3±9,6% Vs 36,8±17,2% (p<0,01) and CS was –12,8±7,5 Vs –19,6%±5,2% (p<0,01). The SL of the RV was reduced (-15,6±5,8% Vs –21,7±1,9%, P <0,01). The SL of the RV> –17,5% was correlated with the occurrence of syncope (OR=5,48; p=0,005). For an average follow-up of 32 months±6 months, the SL of the RV<–17,5% was associated with a better survival without events (88% event-free survival for SL RV <–17,5% Vs 60% for SL VD>–17.5; Log rank p=0,008).Hypertrophic myocardiopathy is a disease of the whole myocardium with a biventricular alteration. The study by Strain 2D can detect subclinical impairment and has a contributive prognostic value for risk stratification of sudden death and guiding the therapeutic strategy.The author hereby declares no conflict of interest