Considering the optimization of blanket performance, it is desired that the bed morphology and packing state during reactor operation are stable and predictable. Both experimental and numerical work are performed to explore the stability of pebble beds, in particular under pulsed loading conditions. Uniaxial compaction tests have been performed for both KIT’s Li4SiO4 and NFRI’s Li2TiO3 pebble beds at elevated temperatures (up to 750°C) under cyclic loads (up to 6MPa). The obtained data shows the stress-strain loop initially moves towards the larger strain and nearly saturates after a certain number of cyclic loading cycles. The characterized FEM CAP material models for a Li4SiO4 pebble bed with an edge-on configuration are used to simulate the thermomechanical behavior of pebble bed under ITER pulsed operations. Simulation results have shown the cyclic variation of temperature/stress/strain/gap and also the same saturation trend with experiments under cyclic loads. Therefore, it is feasible for pebble bed to maintain its packing stability during operation when disregarding pebbles’ breakage and irradiation.