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Expression of proliferating cell nuclear antigen (PCNA) in skin infiltrates and serum levels of soluble interleukin-2 receptor (sIL-2R) were studied in a group of 24 patients with mycosis fugoides (MF) in various clinical stages. The aim of the study was to investigate a possible correlation between these parameters and activity of the disease. Advanced stage skin specimens revealed the highest percentage of PCNA positive cells compared to early stages. The elevated concentration of sIL-2R was detected in all of 2 patients with erythrodermic variant of MF who also presented the high proliferation index. The median value of sIL-2R level was higher in patients with tumor phase compared to patients in patch and plaque stage. No correlation was found between sIL-2R serum level and the expression of membran-bound IL-2R α chain (CD 25) on lymphoid cells in skin lesions. The tudy has indicated that PCNA immunostaining and serum sIL-2R level may be useful prognostic parameters in MF.