The occurrence, in large shelf edge deltas, of gravity driven deformation related to overpressured shales is now well documented in many natural examples. In this paper, we explored the implications of the migration of the delta front on the kinematics of gravity driven deformation, in a case where the stratigraphic framework is detailed enough to discuss deformation kinematics and sedimentary supply at high temporal resolution (×0.1Myr).We determined the deformation for the last 4Myr at the scale of the whole Eastern Niger Delta. The upslope extensional domain showed EW asymmetric grabens. The transitional domain displayed (i) deformation restricted to folding to the east and (ii) a thicker sedimentary wedge and a larger deformation accommodated by thrust related folds to the west. The compressional front was a fold and thrust belt.Extensional deformation decreased in amount and rate over the Plio-Pleistocene. It also evolved significantly from distributed over the whole area to localized either to the western or eastern domains over that period. The compressional deformation followed the same evolution (i.e. the greater the extension, the greater the compression in either time or space), demonstrating the strong coupling between the extensional and compressional domains.Gravity deformation during the Plio-Pleistocene was driven by the continental slope spanning the coastal plain to distal deposits over the oceanic crust (about 2800m of gravity potential). The superimposition of the delta front migration area and the extensional domain show that the associated pressure gradient localized the extensional domain. Deformation was closely linked to migrations of the delta front and the sedimentary supply reaching the delta: (i) the decrease in extension rate over the Plio-Pleistocene is related to a decrease in sedimentary supply over the Plio-Pleistocene, and, (ii) the spatial variations in extension intensity and rate are related to spatial variations of sedimentary supply.