Prebisch's approach to economic development was based on the notion that there is an international historical division of labour. Peripheral countries are specialised in exporting primary goods while Centre countries export industrial goods. The Terms of Trade for peripheral countries tend to deteriorate. This approach can be extended to ecological issues. The international Centre–Periphery division does not only involve the monetary exchange of goods and capital, but also the physical exchange in which Southern countries provide materials and energy so that Northern countries can develop their socioeconomic metabolism. This metabolic process is guaranteed through cheap prices for primary goods. This paper aims to apply and extend Prebisch's thought on unequal exchange, both monetary and ecological, in relation to Colombian trade in the period 1970–2002, using Material Flow Analysis.