In four studies, controlling for social desirability or self-esteem had little impact on a general factor of personality (GFP) as measured by its Big Five loadings. In Study 1, we re-analyzed an Internet study of the 44-item Big Five Inventory (BFI) (N=628,640) and found that controlling for self-esteem only reduced the mean loading from .59 to .56. In Study 2, we analyzed an Internet study of the BFI-10 (N=126) and found that controlling for self-esteem only reduced the mean loading from .55 to .50. In Study 3, we re-analyzed data from the 44-item BFI (N=128) and found that controlling for social desirability or self-esteem only reduced the mean loadings from .58 to .56 and .54, respectively. In Study 4, we re-analyzed data on the 44-item BFI (N=88) and found that controlling for social desirability or self-esteem only reduced the mean loadings from .56 to .55 and .54, respectively. Thus, social desirability and self-esteem do not appear to account for the GFP, suggesting it is substantive rather than an artifact of evaluative bias.