In the period from the 25th March to the 20th October 1942, around 57,700 Jews were deported from the Ludak Slovak Republic to the Nazi concentration and extermination camps. Around 39,000 persons were transported to the Lublin Area where the Reinhardt Operation had been launched, and another 18,700 Jews were taken to the Auschwitz Nazi concentration and extermination camp. The so-called first wave of the deportations of Jews from Slovakia was the culmination of the years-long systemic anti-Jewish policy of the Ludak regime. The aim of this study is to provide a basic overview of the first wave of deportations of Slovak Jews from Slovakia. It explores the motivations of the initiators and organisers of deportations, their organisation and different stages, and briefly covers the locations (places of destination of the transports) at which Slovak Jews found after the deportation. This issue was until recently absent from Slovak scientific literature (mainly when it comes to the Lublin Area).