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Preincubation of Ehrlich ascites tumour cells with millimolar concentrations of pantothenic acid, pantothenol or pantethine, but not with homopantothenic acid, at 22°C or 32°C, but not at 0°C, makes the plasma membrane more resistant to the damaging effect of submillimoiar concentrations of digitonin. It is proposed that this increased resistance is due to the increased rate of cholesterol biosynthesis...
Inhibition of respiration by glucose, known as the Crabtree effect, has been observed in several tumours and some other highly glycolytic cells and tissues. Among mechanisms proposed to explain this effect were: competition between glycolysis and respiration for ADP or for inorganic phosphate, change of intracellular pH, change in the permeability of mitochondrial membranes, specific regulatory behaviour...
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