In 'De rerum natura' (4.469n) Lucretius gives a brief argument against the thesis of 'global' scepticism (i.e. that nothing is, or could be, known) which in his view is self-refuting. The paper presents a detailed analysis of the passage and puts it in a historical context. It is tentatively shown that, pace some modern commentators, the objection could hardly be regarded as aimed at Metrodorus of Chios, a forerunner of Hellenistic scepticism.
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