Lignocellulosic biomass is one of the most abundant renewable resources that can be processed by chemical reactions for the production of value-added products. In the current study, cellulose and methyl cellulose were synthesized from bleached bagasse pulp and were further modified to cellulose derivatives. Cellulose was first extracted from bagasse by acid–alkali pulping process and was derivatized to prepare methyl cellulose. The products were further chemically modified to tosylated methyl cellulose and trimethylsilylated methyl cellulose. The resulting products were investigated by FT-IR and SEM. Cellulose and all derivatives prepared were evaluated as potential pH-sensitive carrier matrices. The effectiveness as carrier was investigated as function of pH and time in various pH solutions, namely 2.0, 3.5 and 5.0. It was indicated that the type of the modified cellulose plays a role in the obtained results. The present work can be considered as a basic line for drug loading and releasing field.
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.