Owing to their controlled solubility, phosphate invert glasses are of interest for use as temporary implant materials or tissue engineering scaffolds for controlled ion release.MgO-CaO-SrO-TiO2-P2O5 invert glasses were prepared and their dissolution behavior and cell response were examined.MgO addition to the phosphate invert glass system improved glass formation, owing to the relatively large field strength of Mg2+ ions. In osteoblastlike MC3T3-E1 cell culture tests, cell numbers on the invert glasses were significantly larger compared with the control, possibly caused by the release of Mg2+ ions promoting enhanced cell adhesion and proliferation. Alkaline phosphatase (ALP) activity varied with glass composition, with higher strontium for calcium substitution (33 to 100%) showing highest ALP activity. This effect may be caused by the release of strontium ions from the glasses.
 Xynos I.D., Edgar A.J., Buttery L.D.K., Hench L.L., Polak J.M.,
Ionic Products of Bioactive Glass Dissolution Increase Proliferation
of Human Osteoblasts and Induce Insulin-Like Growth Factor
II mRNA Expression and Protein Synthesis, J. Biomed.Mater.
Res. 2000, 276, 461–465
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