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Aims
To develop an oral delivery system of glucagon‐like peptide 1 (GLP‐1) (28–36) for treating type‐2 diabetes, B.S‐GLP‐1(28–36), a recombinant Bacillus subtilis spores transformed with a plasmid vector encoding five consecutive GLP‐1 (28–36) nonapeptides with an enterokinase site was constructed.
Methods and Results
GLP‐1(28–36) nonapeptide was successfully expressed on the surface of B. subtilis...
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