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BackgroundMastocytosis is characterized by the accumulation of mast cells (MCs) associated with activating mutations of KIT. Tumor necrosis factor‐related apoptosis‐inducing ligand receptors (TRAIL‐Rs) are preferentially expressed on neoplastic cells and induce the extrinsic apoptotic pathway. Recent studies reported on the expression of TRAIL‐Rs and TRAIL‐induced apoptosis in cultured human MCs,...
Transplantation is invariably associated with ischemia–reperfusion injury (IRI), inflammation and rejection. Resultant cell death has morphological features of necrosis but programmed cell death has been synonymous with apoptosis until pathways of regulated necrosis (RN) have been described. The best‐studied RN pathway, necroptosis, is triggered by perturbation of caspase‐8‐mediated apoptosis and...
Wiedza prawnicza stanowi jedną z istotnych przesłanek rozwoju działalności gospodarczej prowadzonej przez przedsiębiorcę (w tym również przez przedsiębiorcę górniczego). Brak odpowiedniej wiedzy w tym zakresie wiąże się z ujemnymi konsekwencjami, polegającymi m. In. na ponoszeniu kar administracyjnych, a niekiedy może być przyczyną likwidacji przedmiotowej działalności.
BACKGROUND & AIMS: Ligation of CD95 (APO-1/Fas) by antibody or CD95 ligand (CD95L) induces apoptosis and, in some cell lines, growth. Normal colonic epithelial cells constitutively express CD95. The function of CD95 on colonocytes is unknown. The aim of this study was to elucidate the role of epithelial CD95 in the normal colon and in ulcerative colitis. METHODS: Intact colonic crypts were isolated,...
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