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Background: The role of I Ks in the human atrium is unclear. Therefore, the effect of Chromanol 293 B (Chrom), a recently described highly selective I Ks blocker in guinea pig ventricular myocytes, was investigated in human atrial myocytes.Methods: Specimens of human atrial appendages were obtained from patients undergoing coronary bypass surgery. Patients had stable sinus...
Background: Recently, chromanol 293B (chrom) was described as a highly selective I Ks blocker in guinea pig ventricular myocytes. The objektive of the present study was to investigate the kinetics of the I Ks blockade.Methods: Freshly isolated ventricular myocytes of guinea pigs were studied with whole cell patch clamp techniques.Results: Chrom (10 μM) induced a rate-independent...
Background: isolated, totally occluded coronary vessel subtending a non-infarcted, entirely collateral filling-dependent myocardial region provides a unique opportunity to assess the role of angiographically assessed coronary collateral circulation (ACC) in modulating myocardial vulnerability to pharmacological or physiologic stress testing.Objective: To assess whether a high-grade ACC has similar...
Background: Reduced action potential (AP) prolongation of currently used class III antiarrhythmics in the presence of β-adrenergic activation is supposed to be a major disadvantage of this drugs. In particular, I Kr blockade as principle mechanism of class III antiarrhythmic action was supposed to be the reason for this disadvantage, since other depolarising currents, especially I ...
Background: The use of beta-blockers for the acute treatment of acute myocardial infarction (AMI) has been found efficacious in multiple clinical trials and has been endorsed by the AHA/ACC Clinical Practice Guidelines; however, these clinical trials primarily studied low-risk populations consisting of few elderly patients.Methods: To determine the use and effectiveness of beta-blockers in the acute...
Endothelium-dependent vascular relaxation and perfusion are impaired in the collateral-dependent myocardium. To examine the effects of the angiogenic agent vascular endothelial growth factor (VEGF) on these alterations, ameroid constrictors were placed on the proximal circumflex (LCx) coronary artery of pigs. In 6 animals, VEGF was administered extraluminally to the proximal LCx with an implanted...
Systemic administration of L-arginine has been shown to restore endothelial function. However, the feasibility of local delivery without significant endothelial injury is not known. The goal of this study was to determine if local delivery of L-arginine can acutely influence endothelium-dependent vasodilation and increase local nitrogen oxide (NOx) production. 13 New Zealand white rabbits were...
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