Search results for: Xiao-Kang Li

Items from 1 to 20 out of 76 results

article

A Mesenchymal‐Epithelial Transition Factor‐Agonistic Antibody Accelerates Cirrhotic Liver Regeneration and Improves Mouse Survival Following Partial Hepatectomy

Kuai Ma, Weitao Que, Xin Hu, Wen‐Zhi Guo, more

Liver Transplantation > 28 > 5 > 782 - 793

Small‐for‐size syndrome (SFSS) is a common complication following partial liver transplantation and extended hepatectomy. SFSS is characterized by postoperative liver dysfunction caused by insufficient regenerative capacity and portal hyperperfusion and is more frequent in patients with preexisting liver disease. We explored the effect of the Mesenchymal‐epithelial transition factor (MET)‐agonistic...

article

5‐ALA/SFC Attenuated Binge Alcohol–Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats

Chi Liu, Ping Zhu, Masayuki Fujino, Shuoji Zhu, more

Alcoholism: Clinical and Experimental Research > 43 > 8 > 1651 - 1661

Background This study aimed to investigate the protective effect of 5‐aminolevulinic acid (5‐ALA) and sodium ferrous citrate (SFC) against binge alcohol–induced gut leakiness and inflammatory liver disease in HIV transgenic (TG) rats. Methods TG rats were treated with 3 consecutive doses of binge ethanol (EtOH) with or without 5‐ALA/SFC. Blood and liver tissue samples were collected at 6 hours...

article

Liver transplantation: New treatment for mucopolysaccharidosis type VI in rats

Sumika Toyama, Ohsuke Migita, Masayuki Fujino, Tetsuo Kunieda, more

Pediatrics International > 61 > 2 > 180 - 189

Background Mucopolysaccharidosis (MPS) VI is a rare, autosomal recessive congenital metabolic disorder caused by deficient activity of the lysosomal metabolic enzyme, N‐acetylgalactosamine 4‐sulfatase. Enzyme replacement therapy (ERT) is the current treatment for MPS VI, although it involves limited compliance to the therapy and high cost. The aim of this study was to develop a new method of treatment...

article

Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation

Keiichi Uto, Seisuke Sakamoto, Weitao Que, Keita Shimata, more

BMC Gastroenterology > 2019 > 19 > 1 > 1-9

Background Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from marginal donors. The attenuation of ischemia-reperfusion injury (IRI) in such marginal donors is therefore crucial for reducing the possibility of the primary non-function of grafts and...

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Combination of 5‐aminolevulinic acid and iron prevents skin fibrosis in murine sclerodermatous graft‐versus‐host disease

Chi Liu, Xue Yang, Ping Zhu, Masayuki Fujino, more

Experimental Dermatology > 27 > 10 > 1104 - 1111

Scleroderma or systemic sclerosis (SSc) is a clinically heterogeneous rheumatological autoimmune disease affecting the skin, internal organs and blood vessels. There is at present no effective treatment for this condition. Our study investigated the effects of 5‐aminolevulinic acid (5‐ALA), which is a precursor of haem synthesis, on graft‐vs‐host disease (GvHD)‐induced SSc murine model. Lymphocytes...

article

Protective role of heme oxygenase-1 in fatty liver ischemia–reperfusion injury

Shaowei Li, Masayuki Fujino, Terumi Takahara, Xiao-Kang Li

Medical Molecular Morphology > 2019 > 52 > 2 > 61-72

Ischemia–reperfusion (IR) injury is a kind of injury resulting from the restoration of the blood supply after blood vessel closure during liver transplantation and is the main cause of graft failure. The pathophysiological mechanisms of hepatic IR include a variety of oxidative stress responses. Hepatic IR is characterized by ischemia and hypoxia inducing oxidative stress, immune response and apoptosis...

article

Oral administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in peripheral blood mononuclear cells of healthy human subjects in combination with ferrous iron

Hidenori Ito, Yoshiaki Nishio, Takeshi Hara, Hidemitsu Sugihara, more

European Journal of Pharmacology > 2018 > 833 > C > 25-33

Heme oxygenase-1 (HO-1) is a major anti-inflammatory enzyme and a key regulator that induces immune tolerance through affecting the differentiation of dendritic cells. The aim of this study is to determine whether the combination of 5-aminolevulinic acid (ALA) and iron induces HO-1 expression in healthy human peripheral blood mononuclear cells (PBMC).The study was an open labeled, non-randomized,...

article

Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease

Yi-xiang Xu, Huan Wang, Xiao-kang Li, Sheng-nan Dong, more

European Journal of Medicinal Chemistry > 2018 > 143 > C > 33-47

A series of novel propargylamine-modified pyrimidinylthiourea derivatives (1–3) were designed and synthesized as multifunctional agents for Alzheimer's disease (AD) therapy, and their potential was evaluated through various biological experiments. Among these derivatives, compound 1b displayed good selective inhibitory activity against AChE (vs BuChE, IC₅₀ = 0.324 μM, SI > 123) and MAO-B (vs MAO-A,...

article

Enhancement clay tolerance of PCE by lignin-based polyoxyethylene ether in montmorillonite-contained paste

Xiao-Kang Li, Da-Feng Zheng, Tao Zheng, Xu-Liang Lin, more

Journal of Industrial and Engineering Chemistry > 2017 > 49 > C > 168-175

The dispersion ability of polycarboxylate ether (PCE) in fresh concrete is much impeded by clay impurities. To improve the dispersion of PCE in the clay-contained concrete, lignin-based polyoxyethylene ether (PEG-grafted-lignin) was synthesized through polyethylene glycol (PEG) grafted to kraft lignin (KL). The results showed that PEG-grafted-lignin increased the fluidity of MMT-contained cement paste...

article

iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells

Songjie Cai, Jiangang Hou, Masayuki Fujino, Qi Zhang, more

Stem Cell Reports > 2017 > 8 > 5 > 1174-1189

Regulatory dendritic cell (DCregs)-based immunotherapy is a potential therapeutic tool for transplant rejection. We generated DCregs from murine induced pluripotent stem cells (iPSCs), which could remain in a “stable immature stage” even under strong stimulation. Harnessing this characteristic, we hypothesized that iPS-DCregs worked as a negative vaccine to generate regulatory T cells (Tregs), and...

article

5-Aminolevulinic acid with sodium ferrous citrate induces autophagy and protects cardiomyocytes from hypoxia-induced cellular injury through MAPK-Nrf-2-HO-1 signaling cascade

Mingyi Zhao, Ping Zhu, Masayuki Fujino, Yoshiaki Nishio, more

Biochemical and Biophysical Research Communications > 2016 > 479 > 4 > 663-669

Hypoxia causes cardiac disease via oxidative stress and mitochondrial dysfunction. 5-Aminolevulinic acid in combination with sodium ferrous citrate (ALA/SFC) has been shown to up-regulate heme oxygenase-1 (HO-1) and decrease macrophage infiltration and renal cell apoptosis in renal ischemia injury mice. However, its underlying mechanism remains largely unknown. The aim of this study was to investigate...

article

Investigation of grafted sulfonated black liquor as wet‐ready mortar admixture

Da‐Feng Zheng, Ran Chen, Xiao‐Kang Li

Environmental Progress & Sustainable Energy > 35 > 5 > 1395 - 1399

In order to develop a new mortar admixture and effectively apply black liquor, effect of grafted sulfonated black liquor on wet‐ready mortar property was investigated. The results showed that when the molar ratio of sodium sulfite/formaldehyde/acetone was 0.5:2:1, the polycondensation reaction time was 2.5 h at 95°C, the sulfonation degree of the product was 2.93 mmol·g⁻¹ and the average molecular...

article

Numerical Investigation of T-joints with 3D Four Directional Braided Composite Fillers Under Tensile Loading

Xiao-kang Li, Zhen-guo Liu, Long Hu, Yi-bo Wang, more

Applied Composite Materials > 2017 > 24 > 1 > 171-191

Numerical studied on T-joints with three-dimensional four directional (3D4D) braided composite fillers was presented in this article. Compared with conventional unidirectional prepreg fillers, the 3D braided composite fillers have excellent ability to prevent crack from penetrating trigone fillers, which constantly occurred in the conventional fillers. Meanwhile, the 3D braided composite fillers had...

article

5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction

Masayuki Fujino, Yoshiaki Nishio, Hidenori Ito, Tohru Tanaka, more

International Immunopharmacology > 2016 > 37 > C > 71-78

5-Aminolevulinic acid (5-ALA) is a naturally occurring amino acid and precursor of heme and protoporphyrin IX (PpIX). Exogenously administrated 5-ALA increases the accumulation of PpIX in tumor cells specifically due to the compromised metabolism of 5-ALA to heme in mitochondria. PpIX emits red fluorescence by the irradiation of blue light and the formation of reactive oxygen species and singlet oxygen...

article

Formation of heterocaryotic and homonuclear bridged–dimeric complexes on surface

Yan-Fang Geng, Shi-Li Wu, Jing Xu, Hong-Liang Dai, more

Chinese Chemical Letters > 2016 > 27 > 4 > 602-606

The formation of coordinated dimeric complexes bridged by axial ligands on surface is observed with the help of a 1,3,5-tris(10-carboxydecyloxy)benzene (TCDB) template through scanning tunneling microscopy (STM). STM images of molecular adlayers of zinc tetraphenylporphyrin (ZnTPP), zinc phthalocyanine (ZnPc), and their mixture are reported. ZnTPP and ZnPc can spontaneously form highly an ordered...

article

Impaired CD98 signaling protects against graft-versus-host disease by increasing regulatory T cells

Yoshiaki Nishio, Masayuki Fujino, Songjie Cai, Yuya Kitajima, more

Transplant Immunology > 2016 > 35 > C > 34-39

Graft-versus-host disease (GvHD) is a major barrier to the broader use of allogenic hematopoietic stem cell transplantation for non-malignant clinical applications. A murine model of C57BL/6 to B6D2F1 acute GvHD was employed with T lymphocytes harboring a deletion of the CD98 heavy chain (CD98hc^−/−) as donor cells. The CD98hc^−/− resulted in lower responses to alloantigen stimulation in a mixed leukocyte...

article

5-Aminolevulinic acid combined with ferrous iron ameliorate ischemia–reperfusion injury in the mouse fatty liver model

Shaowei Li, Terumi Takahara, Xiao-Kang Li, Masayuki Fujino, more

Biochemical and Biophysical Research Communications > 2016 > 470 > 4 > 900-906

The fatty liver could increase the risk of serious acute ischemia reperfusion (I/R) injury, and hepatic steatosis is indeed a major risk factor for hepatic failure after grafting a fatty liver.Fatty liver models of methionine- and choline-deficient high-fat mice were subjected to I/R injury with or without 5-aminolevulinic acid (5-ALA)/sodium ferrous citrate (SFC) treatment. Levels of hepatic enzymes,...

article

Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting

Hai Huang, Ping-Heng Lan, Yong-Quan Zhang, Xiao-Kang Li, more

Surface & Coatings Technology > 2015 > 283 > Complete > 80-88

Porous titanium with high strength and a low elastic modulus has received attention as an excellent orthopedic implant; however, the fabrication and biological performance of porous implant both need to be improved. A porous Ti6Al4V implant (TI) was prepared using the electron beam melting method, and some samples underwent surface modification with a hydroxyapatite coating (HA-TI) by plasma-spraying...

article

First-principles calculation of sulfur–selenium segregation in ZnSe1−xSx: The role of lattice vibration

Xiao-Kang Li, Hong-Tao Xue, Fu-Ling Tang, Wen-Jiang Lu

Materials Science in Semiconductor Processing > 2015 > 39 > Complete > 96-102

First-principles phase diagram calculations based on density functional theory within the generalized gradient approximation in combination with Monte Carlo (MC) techniques and cluster expansion were performed for the ZnSe_1−xS_x alloys. Formation energies were used as a basis for fitting cluster expansion Hamiltonians. All formation energies of ZnSe_1−xS_x alloys are positive, showing that ZnSe_1−xS_x...

article

Dihydroquercetin (DHQ) ameliorated concanavalin A-induced mouse experimental fulminant hepatitis and enhanced HO-1 expression through MAPK/Nrf2 antioxidant pathway in RAW cells

Mingyi Zhao, Jiajie Chen, Ping Zhu, Masayuki Fujino, more

International Immunopharmacology > 2015 > 28 > 2 > 938-944

Autoimmune hepatitis represents a ubiquitous human health problem and has a poor prognosis. Dihydroquercetin (DHQ), a well-known antioxidant, significantly inhibits fulminant hepatitis through anti-oxidant and anti-inflammation mechanisms. In this study, we show that administration of DHQ ameliorated concanavalin A (ConA)-induced mouse liver injury by increasing the survival rate, reducing the serum...

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INFONA - science communication portal

Search results for: Xiao-Kang Li

A Mesenchymal‐Epithelial Transition Factor‐Agonistic Antibody Accelerates Cirrhotic Liver Regeneration and Improves Mouse Survival Following Partial Hepatectomy

5‐ALA/SFC Attenuated Binge Alcohol–Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats

Liver transplantation: New treatment for mucopolysaccharidosis type VI in rats

Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation

Combination of 5‐aminolevulinic acid and iron prevents skin fibrosis in murine sclerodermatous graft‐versus‐host disease

Protective role of heme oxygenase-1 in fatty liver ischemia–reperfusion injury

Oral administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in peripheral blood mononuclear cells of healthy human subjects in combination with ferrous iron

Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease

Enhancement clay tolerance of PCE by lignin-based polyoxyethylene ether in montmorillonite-contained paste

iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells

5-Aminolevulinic acid with sodium ferrous citrate induces autophagy and protects cardiomyocytes from hypoxia-induced cellular injury through MAPK-Nrf-2-HO-1 signaling cascade

Investigation of grafted sulfonated black liquor as wet‐ready mortar admixture

Numerical Investigation of T-joints with 3D Four Directional Braided Composite Fillers Under Tensile Loading

5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction

Formation of heterocaryotic and homonuclear bridged–dimeric complexes on surface

Impaired CD98 signaling protects against graft-versus-host disease by increasing regulatory T cells

5-Aminolevulinic acid combined with ferrous iron ameliorate ischemia–reperfusion injury in the mouse fatty liver model

Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting

First-principles calculation of sulfur–selenium segregation in ZnSe1−xSx: The role of lattice vibration

Dihydroquercetin (DHQ) ameliorated concanavalin A-induced mouse experimental fulminant hepatitis and enhanced HO-1 expression through MAPK/Nrf2 antioxidant pathway in RAW cells

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