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Mast cells are a critical component of allergic responses in humans, and animal models that allow the in vivo investigation of their contribution to allergy and evaluation of new human-specific therapeutics are urgently needed.To develop a new humanized mouse model that supports human mast cell engraftment and human IgE-dependent allergic responses.This model is based on the NOD-scid IL2rgnull SCF/GM-CSF/IL3...
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