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Insomnia is a common problem for people with chronic pain. Cortical GABAergic neurons are part of the neurobiological substrate that underlies homeostatic sleep regulation. In the present study, we confirmed that sciatic nerve ligation caused thermal hyperalgesia and tactile allodynia in mice. In this experimental model for neuropathic pain, we found an increase in wakefulness and a decrease in non-rapid...
3-Oxo-7-hydroxy-3,7-secorhynchophylline (1), an oxindole alkaloid found in Uncaria attenuata, was prepared from isorhynchophylline (2), and two diastereomers ascribable to C7 of the natural and semi-synthetic 1 were separated by chiral column chromatography. The absolute configuration at C7 was elucidated by comparison of the CD spectra with those of the known oxytryptophan derivatives (8a and 8b)...
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