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The ability to sense and to respond to changes in the nutrient availability is an essential feature for the survival of every organism. Saccharomyces cerevisiae has several signal transduction cascades to optimally adapt its metabolism to the availability of nutrients in the environment. In this chapter, we focus on the convergence of signal transduction pathways for nutrient sensing in budding yeast...
The ability to sense and to respond to changes in the nutrient availability is an essential feature for the survival of every organism. Saccharomyces cerevisiae has several signal transduction cascades to optimally adapt its metabolism to the availability of nutrients in the environment. In this chapter, we focus on the convergence of signal transduction pathways for nutrient sensing in budding yeast...
The antifungal plant defensin DmAMP1 interacts with the fungal sphingolipid mannosyl diinositolphosphoryl ceramide (M(IP) 2 C) and induces fungal growth inhibition. We have identified SKN1, besides the M(IP) 2 C-biosynthesis gene IPT1, as a novel DmAMP1-sensitivity gene in Saccharomyces cerevisiae. SKN1 was previously shown to be a KRE6 homologue, which is involved in β-1,6-glucan...
The highly conserved Tor kinases (TOR) and the protein kinase A (PKA) pathway regulate cell proliferation in response to growth factors and/or nutrients. In Saccharomyces cerevisiae, loss of either TOR or PKA causes cells to arrest growth early in G 1 and to enter G 0 by mechanisms that are poorly understood. Here we demonstrate that the protein kinase Rim15 is required for entry into...
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