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We developed a method for automated quantification of myocardial perfusion from cardiac magnetic resonance (CMR) images. Our approach uses region-based and edge-based level set techniques for endocardial and epicardial border detection combined with non-rigid registration achieved by a 2D multi-scale cross-correlation and contour adaptation. This method was tested on 66 short-axis image sequences...
Cardiac resynchronization therapy (CRT) has been successfully used in patients affected by heart failure and left ventricular (LV) systolic dysfunction with LV dissyncrony. However, a variable number of patients (20%-30%) do not respond favorably to CRT due to several possible, still uncertain factors. One possible cause is the displacement of the electrode tip from effectively resynchronizing stimulation...
Small animal positron emission tomography (PET) image quantitation is severely affected by partial volume effect (PVE) caused by the spatial resolution of PET tomographs. The aim of this work was to reduce the PVE using a modified iterative expectation maximization (EM) reconstruction algorithm. The goal of the method was to increase the accuracy of tracer concentration values in order to obtain an...
Interest in left ventricular (LV) mechanics has recently focused on detailed 3D analysis of LV deformations. Our goal is to investigate transmural strain variability within the normal ventricle and during the early stages of ischemia using sonomicrometric crystals implanted into canine LV wall. In this study 3 open chest dog models were implanted in a two-tetrahedron configuration with three crystals...
Evaluation of aorta morphology and function in presence of aneurysms or dissection is crucial for a correct treatment choice between surgical resection and percutaneous stent-graft deployment. We developed and tested a new method for automated dynamic aorta segmentation from computed tomography (CT) images from which static and dynamic parameters of aortic morphology and function can be automatically...
Two-dimensional echocardiography (2DE) is routinely used in clinical practice to measure left ventricular (LV) mass, dimensions, and function. The reliability of these measurements is highly dependent on the ability to obtain nonforeshortened long axis (LA) images of the left ventricle from transthoracic apical acoustic windows. Real time three-dimensional echocardiography (RT3DE) is a novel imaging...
We developed a new method for "nearly-automated" carotid (CA) contour detection by combining seeded region growing (SRG) and level-set (LS) methods. This technique was applied to cross-sectional vascular images (Aspen, Siemens) acquired during parabolic flight in 5 normal subjects, to detect carotid area changes with gravity (Gz). For each frame, the region resulting from SRG was used to...
Right ventricular (RV) volume quantification from cardiac magnetic resonance imaging is based on manual tracing of endocardial boundaries and application of geometric modeling. This procedure is subjective, time-consuming and may bias volume measurements since the right ventricle is a complex structure that is not well suited to a geometric model. We developed a technique for RV endocardial surface...
The measurement of left ventricular (LV) long axis length (LAL) is an integral part of echocardiographic evaluation of LV volume, the most important determinant of LV systolic function. LAL measurements from 2D echocardiography (2DE) are highly dependent on the ability to obtain non-foreshortened LV images. Real-time 3D echocardiography (RT3DE) could potentially overcome the effects of long-axis foreshortening,...
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