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We developed a method for automated quantification of myocardial perfusion from cardiac magnetic resonance (CMR) images. Our approach uses region-based and edge-based level set techniques for endocardial and epicardial border detection combined with non-rigid registration achieved by a 2D multi-scale cross-correlation and contour adaptation. This method was tested on 66 short-axis image sequences...
Small animal positron emission tomography (PET) image quantitation is severely affected by partial volume effect (PVE) caused by the spatial resolution of PET tomographs. The aim of this work was to reduce the PVE using a modified iterative expectation maximization (EM) reconstruction algorithm. The goal of the method was to increase the accuracy of tracer concentration values in order to obtain an...
The goal of this work was to improve the image quality of small animal PET images by introducing in the reconstruction process the true system point spread function (PSF) and an anatomical image prior. Simulations were performed using a mouse heart phantom (myocardium and ventricles) and a comparison between standard EM reconstruction and EM with PSF modelling and anatomical prior was performed. The...
The recently developed echocardiographic matrix array transesophageal (mTEE) transducer provides real-time 3D images of high spatial and temporal resolution that may be suitable for detailed simultaneous study of functional anatomy of the mitral and aortic valves. We developed software that detects and tracks throughout the cardiac cycle mitral and aortic annuli (MA and AoA) and tested it in 15 patients...
We developed a technique for automated identification of 3D myocardial ROI suitable for translation-free quantification of myocardial videointensity over time, MVI(t), from RT3DE images. Our software was tested on 12 ECG-triggered RT3DE datasets obtained in pigs during transient contrast inflow. Analysis included: (1) semi-automated detection of endo- and epicardial surfaces using level-set techniques...
Evaluation of aorta morphology and function in presence of aneurysms or dissection is crucial for a correct treatment choice between surgical resection and percutaneous stent-graft deployment. We developed and tested a new method for automated dynamic aorta segmentation from computed tomography (CT) images from which static and dynamic parameters of aortic morphology and function can be automatically...
Assessment of left ventricular (LV) size and function from cardiac magnetic resonance (CMR) images requires manual tracing of LV borders on multiple 2D slices, which is subjective, experience dependent, tedious and time-consuming. We tested a new method for automated dynamic segmentation of CMR images based on a modified region-based model, in which a level set function minimizes a functional containing...
Tissue Doppler is used to evaluate mitral annulus (MA) dynamics. This technique has two major limitations: it is two-dimensional and angle-dependent. To solve these limitations, our aim was to develop and test a tool for automated 3D tracking and quantification of the MA motion throughout the cardiac cycle by using real-time 3D echocardiography (RT3DE). The tracking algorithm was developed using a...
Quantification of left ventricular (LV) function from the analysis of real-time 3D echocardiographic (RT3DE) data does not fully exploit the dynamic volumetric information contained in these data. Accordingly, we developed a volumetric analysis technique aimed at quantification of global and regional LV function. RT3DE images were analyzed using custom software to extract global and partial volumes...
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