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Aortic stenosis (AS) is the most common native valve disease. The assessment of its severity is routinely performed using transthoracic 2D echocardiography. In particular, aortic valve area (AVA) is usually assessed by continuity equation, although this measurement relies on geometrical assumptions, or by planimetry on transesophageal echocardiography. Accordingly, the aim of this study was to develop...
Simplified action potential ??minimal?? models, whilst not being able to explain the ionic mechanisms of cardiac action potential, can be useful for cardiac simulation purposes if the model possesses certain basic properties. In this work, we have analyzed one of these ??minimal models?? (the Bueno model) to investigate its ability to simulate ischemia. We modified the model by adding a new ischemic...
Small animal positron emission tomography (PET) image quantitation is severely affected by partial volume effect (PVE) caused by the spatial resolution of PET tomographs. The aim of this work was to reduce the PVE using a modified iterative expectation maximization (EM) reconstruction algorithm. The goal of the method was to increase the accuracy of tracer concentration values in order to obtain an...
Assessment of left ventricular (LV) size and function from cardiac magnetic resonance (CMR) images requires manual tracing of LV borders on multiple 2D slices, which is subjective, experience dependent, tedious and time-consuming. We tested a new method for automated dynamic segmentation of CMR images based on a modified region-based model, in which a level set function minimizes a functional containing...
A differential, nonlinear model of patients under hemodialytic treatment has been used to analyze the patient's state during the dialysis and to evaluate the optimal temporal course to be assigned to the dialysis variables (ultrafiltration rate and dialysate sodium concentration) in order to obtain prescribed changes in the patient's biological variables. Examples show how the model is able to predict...
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