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Insufficient, underactive, or inappropriate osteoblast function results in serious clinical conditions such as osteoporosis, osteogenesis imperfecta and fracture nonunion and therefore the control of osteogenesis is a medical priority. In vitro mesenchymal stem cells (MSCs) can be directed to form osteoblasts through the addition of soluble factors such as β‐glycerophosphate, ascorbic acid, and dexamethasone;...
Synthetic, porous silicate‐substituted calcium phosphate bone graft matrices (SiCaP; 0.8 wt % Si) with varying strut porosity were applied to ovine critical‐sized defect sites as either 1–2 mm microgranules (SiCaP‐23G, SiCaP‐32G, and SiCaP‐46G) or 1–2 mm microgranules in an aqueous poloxamer carrier (SiCaP‐23P, SiCaP‐32P, and SiCaP‐46P). Defect sites treated with SiCaP‐23G or SiCaP‐23P showed evidence...
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