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Kinetic analysis of the hydrolysis of the peptide H-Vat-Ser-Gin-Asn-Tyr*Pro-He-Val-Gin-NH 2 and its analogs obtained by varying the length and introducing substitutions at the P 4 site was carried out with both HIV-1 and HIV-2 proteinases. Deletion of the terminal Val and Gin had only moderate effect on the substrate hydrolysis, while the deletion of the P 4 , Ser as well as...
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