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The development of addictive states in response to chronic opioid use may be regulated partially by the release of endogenous peptides. These anti-opiate peptides (AOP) are secreted or released into the CNS and produce diverse actions that counterbalance the effects of prolonged opiate exposure. Though the mechanism(s) by which these peptides exert their physiological properties remain largely unknown,...
There is some indication that anti-opiate peptides (AOP) modulate opioid receptor systems by altering μ-receptor density. To further characterize this phenomenon, we investigated the effects of continuous infusion of anti-AOP IgG on μ binding sites in the brains of rats. Specifically, male Sprague-Dawley rats received intracerebroventricular (ICV) infusions for 13 days of either control (rabbit) IgG...
The effect of continuous ICV infusion of NPFF (10 μg/μl) and morphine (40 μg/μl) on mu-opioid binding sites was examined in rats using the in vitro radiolabeled techniques of whole-brain homogenate receptor binding and quantitative autoradiography. Mu receptors were labeled with [ 3 H][d-Ala 2 -MePhe 4 ,Glyol 5 ] enkephalin in the homogenate binding experiments and...
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