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Using guinea pig, rat, and human brain membranes depleted of μ and δ receptors by pretreatment with the site-directed acylating agents BIT (μ selective) and FIT (δ selective), previous studies from our laboratory resolved two subtypes of the κ 2 binding site, termed κ 2a and κ 2b . In more recent studies, we used 6β-[ 125 Iodo]-3,14-dihydroxy-17-cyclopropylmethyl-4,5α-epoxymorphinan...
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