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The effects of tetrandrine (TET), a Ca 2 +antagonist of bis-benzylisoquinoline alkaloid origin, on cultured single bovine pulmonary artery endothelial cells were examined using fluorescence ratio imaging and whole-cell attached patch-clamp techniques. Thapsigargin (TSG, 100 nM), a selective endoplasmic reticulum Ca 2 +-ATPase pump inhibitor known to induce the release of nitric oxide...
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