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Calmodulin (CaM) is a key modulator of the channel gating function of the ryanodine receptor (RyR).The purpose of this study was to investigate the pathogenic role of RyR-bound CaM in diastolic Ca2+ leakage from the sarcoplasmic reticulum and arrhythmogenesis in pressure-overloaded heart failure.Pressure overload was induced in 12-week-old mice by transverse aortic constriction (TAC) using a 27-gauge...
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