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PIK‐75 ist ein α‐Isoform‐selektiver Phosphoinositid‐3‐Kinase(PI3K)‐Inhibitor mit hoher Potenz. Obwohl veröffentlichte SAR‐Daten die Wichtigkeit der NO2‐ und Br‐Substituenten in PIK‐75 zeigen, konnte bisher keine Studie die zugrundeliegende Ursache der Bedeutung korrekt bestimmen. In dieser Zuschrift beschreiben wir die erste Kristallstruktur von PIK‐75 im Komplex mit der Kinase GSK‐3β. Die Struktur...
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