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The biosynthetic gene cluster of antifungal agent jawsamycin (FR‐900848) has been identified by heterologous expression. A series of gene inactivations and in vitro and in vivo analysis of key enzymes in the biosynthetic pathway established their functions. A novel mechanism involving a radical S‐adenosyl methionine (SAM) cyclopropanase collaborating with an iterative polyketide synthase is proposed...
The biosynthetic pathway of a potent antifungal agent, FR-900848, has been examined by administration of several 13 C-labeled precursors to Streptoverticillium fervens HP-891. Although none of the 13 C-labeled acetate was incorporated into FR-900848, the labeling pattern of FR-900848 derived from d-[U- 13 C 6 ]glucose revealed that the fatty acid backbone of FR-900848...
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