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This research presented an annealing strategy to identify hairpin DNA from coil DNA with the same base composition but different arrangements using electrospray mass spectrometry (ESI-MS). A series of single-stranded DNA were annealed with their complementary sequences, respectively. All the five pairs of hairpin DNA and coil DNA were unambiguously distinguished by ESI-MS with annealing strategy....
A new series of N 1 -acetylamino-(5-alkyl/aryl-1,3,4-thiadiazole-2-yl)-5-fluorouracil derivatives were designed and synthesized. These compounds have not been reported in literature, and their structure chemical were confirmed by IR, 1 H NMR and MS (HRMS). The results of antitumor inhibitory activity test showed that some compounds possess more potent antitumor inhibitory activity...
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