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Ferroptosis, as a non‐apoptotic cell death pathway, has attracted increasing attention for cancer therapy. However, the clinical application of ferroptosis‐participated modalities is severely limited by the low efficiency owing to the intrinsic intracellular regulation pathways. Herein, chlorin e6 (Ce6) and N‐acetyl‐l‐cysteine‐conjugated bovine serum albumin‐ruthenium dioxide is elaborately designed...
Increasing the yield of reactive oxygen species (ROS) to enhance oxidative stress in cells is an eternal goal in cancer therapy. In this study, BiVO4 artificial nanozyme is developed with adjustable vanadium vacancy for ultrasound (US) enhanced piezoelectric/sonodynamic therapy. Under US excitation, the vanadium vacancy‐rich BiVO4 nanosheets (abbreviated Vv‐r BiVO4 NSs) facilitate the generation of...
Heterostructured materials integrate the advantages of adjustable electronic structure, fast electron/ions transfer kinetics, and robust architectures, which have attracted considerable interest in the fields of rechargeable batteries, photo/electrocatalysis, and supercapacitors. However, the construction of heterostructures still faces some severe problems, such as inferior random packing of components...
Hypoxic Tumor Therapy
In article number 2200786, Lili Feng, He Ding, Piaoping Yang, and co‐workers develop a near‐infrared (NIR)–triggered nanoplatform with controlled release of a heat shock proteins (HSPs) inhibitor for synergistic mild photothermal and enhanced Fenton nanocatalysis. Upon NIR irradiation, gambogic acid is released and inhibits the expression of HSP90. Notably, the nanoplatform simultaneously...
Mild photothermal therapy (PTT, <45 °C) can prevent tumor metastasis and heat damage to normal tissue, compared with traditional PTT (>50 °C). However, its therapeutic efficacy is limited owing to the hypoxic tumor environment and tumor thermoresistance owing to the overproduction of heat shock proteins (HSPs). Herein, a near‐infrared (NIR)‐triggered theranostic nanoplatform (GA‐PB@MONs@LA)...
Multimodal synergistic therapy based on photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) has attracted increasing attention in cancer therapy. However, the scant therapeutic efficiency is always a barrier for further application. Herein, a smart tumor microenvironment (TME) responsive nanocatalysts are developed by adopting Fe–Mn layered double hydroxides (FeMn‐LDH)...
It is absolutely imperative for development of material science to adjust upconversion luminescence (UCL) properties of highly doped upconversion nanoparticles (UCNPs) with special optical properties and prominent application prospects. In this work, featuring NaHoF4@NaYbF4 (Ho@Yb) structures, sub‐30 nm core–multishell UCNPs are synthesized with a small NaHoF4 core and varied Gd3+/Yb3+ coexisting...
Here a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)‐platinum(IV) (Pt(IV))‒ZnFe2O4, denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near‐infrared light can convert low energy photons to high energy ones, which act as the UV–vis source to simultaneously...
The electrochemical reduction of carbon dioxide (CO2) is an emerging route for curbing excessive CO2 emissions and producing add‐valued chemicals. In article number 1703314, Jinlong Gong and co‐workers introduce controlled synthesis of shapecontrolled and composition‐regulatory Pd–Cu nanocatalysts by a one‐pot approach. A highly efficient performance and tunable product distribution were achieved...
Electrochemical conversion of carbon dioxide (electrochemical reduction of carbon dioxide) to value‐added products is a promising way to solve CO2 emission problems. This paper describes a facile one‐pot approach to synthesize palladium–copper (Pd–Cu) bimetallic catalysts with different structures. Highly efficient performance and tunable product distributions are achieved due to a coordinative function...
The low reactive oxygen species production capability and the shallow tissue penetration of excited light (UV) are still two barriers in photodynamic therapy (PDT). Here, Au cluster anchored black anatase TiO2−x nanotubes (abbreviated as Au25/B‐TiO2−x NTs) are synthesized by gaseous reduction of anatase TiO2 NTs and subsequent deposition of noble metal. The Au25/B‐TiO2−x NTs with thickness of about...
Near infrared (NIR) light triggered phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) affords superior outcome in cancer treatment. However, the reactive oxygen species (ROS) generated by NIR‐excited upconversion nanostructure is limited by the feeble upconverted light which cannot activate PDT agents efficiently. Here, an IR‐808 dye sensitized upconversion nanoparticle...
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