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Chirality‐Guided Diversification
High‐throughput transcriptional‐metabolic pipeline profiling and network analysis characterized gene‐expression and chemical‐variation landscape of chirality‐guided lineage diversification. In article number 2306400, Minghua Liu, Chuanliang Feng, Yan Wei, Xuliang Deng, and co‐workers found chirality‐ordered transcriptomic‐metabolic regulatory networks, emphasizing...
Chirality‐directed stem‐cell‐fate determination involves coordinated transcriptional and metabolomics programming that is only partially understood. Here, using high‐throughput transcriptional‐metabolic profiling and pipeline network analysis, the molecular architecture of chirality‐guided mesenchymal stem cell lineage diversification is revealed. A total of 4769 genes and 250 metabolites are identified...
Nanozymes, as one of the most efficient reactive oxygen species (ROS)‐scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving the catalytic efficiency of Pt‐based nanozymes (e.g., PtCu, one of the best systems), they still display quite limited ROS scavenging capacity and ROS‐dependent antibacterial effects on bacteria or immunocytes,...
The repair of bone defects in diabetes remains a major challenge in the field of biomedicine because of the disturbance of bone immune homeostasis and the susceptibility of exposed wounds to bacterial infection. Clinically, immunoregulation by removing excessive reactive oxygen species (ROS) effectively promotes diabetic bone defect repair. However, aggressive ROS clearance can disrupt ROS homeostasis,...