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In order to explore the role of mitochondria in proliferation promotion and/or apoptosis induction of lanthanum, the mutual influences between La3+ and Ca2+ on mitochondrial permeability transition pore (PTP) opening were investigated with isolated mitochondria from rat liver. The experimental results revealed that La3+ influence the state of mitochondria in a concentration-dependent biphasic manner...
It is well known that the activity of calcineurin (CaN) could be modulated by several transitional metal ions. In the present work, the effects of a calcium analog, lanthanum ion (La3+), on the activity of CaN were studied. It was found that La3+ exerted multiple effects on CaN activity. La3+ could stimulate CaN in the absence of calmodulin (CaM); whereas at low concentrations of La3+, there was a...
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