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Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. We previously investigated the effects of loading of cyclic mechanical stretch on the activaties of JNK and p38 in MC3T3-E1 osteoblastic cells, and observed that JNK and p38 were activated by the mechanical stress. The patterns...
Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. In this study we determined the effects of cyclic mechanical stretch of varying magnitudes and durations on the activation of JNK and p38 in MC3T3-E1 cells. Phosphorylation of both JNK and p38 was observed 5 min after the onset...
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