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The 3C-like protease of SARS coronavirus (SARS-CoV 3CL pro ) is vital for SARS-CoV replication and is a promising drug target. It has been extensively proved that only the dimeric enzyme is active. Here we discovered that two adjacent mutations (Ser139_Ala and Phe140_Ala) on the dimer interface resulted in completely different crystal structures of the enzyme, demonstrating the distinct roles...
Peroxisome proliferator-activated receptors (PPARs) belong to the members of the nuclear receptor superfamily, and play important roles in lipid and glucose homeostasis. Residue Phe282 in PPARγ (Phe273 in PPARα), beyond the ligand-binding site, is a conserved amino acid across several nuclear receptors and in all PPAR subfamily. In this work, we firstly investigated the influence of Phe282(273)Ala...
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