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Recombinant interleukin-1 (rIL-1) is known to inhibit glucose-induced insulin secretion by islets of Langerhans, a novel target tissue of cytokine. We have investigated whether rIL-1 pretreatment affects biochemical mechanisms known to be involved in the regulation of Ca 2+ homeostasis during glucose-induced insulin secretion. Glucose-induced Ca 2+ uptake by intact islets...
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