Search results for: James R. Baker

Items from 1 to 20 out of 144 results

article

Recent patents in allergy and immunology: Transepidermal water loss for anaphylaxis monitoring

Charles F. Schuler, Nicholas W. Lukacs, James R. Baker

Allergy > 79 > 3 > 765 - 766

article

A Light‐Induced Decarboxylative‐Elimination of Substituted Maleimides as a Strategy Towards Triggered Photorelease

Roshni Malde, Daniel A. Richards, Luigia Salerno, Yanbo Zhao, more

European Journal of Organic Chemistry > 26 > 19 > n/a - n/a

Herein we report on photodecarboxylations of various substituted maleimides, resulting in an elimination reaction. Furthermore, we establish facile wavelength tunability through modulation of the maleimide double bond substituents. We envisage that these versatile reagents, which are readily constructed and diversified by nucleophilic substitution reactions on bromomaleimides, will offer new opportunities...

article

Intranasal delivery of allergen in a nanoemulsion adjuvant inhibits allergen‐specific reactions in mouse models of allergic airway disease

James R. Baker, Andrew J. Rasky, Jeffrey J. Landers, Katarzyna W. Janczak, more

Clinical & Experimental Allergy > 51 > 10 > 1361 - 1373

Background Atopic diseases are an increasing problem that involve both immediate hypersensitivity reactions mediated by IgE and unique cellular inflammation. Many forms of specific immunotherapy involve the administration of allergen to suppress allergic immune responses but are focused on IgE‐mediated reactions. In contrast, the effect of allergen‐specific immunotherapy on allergic inflammation...

article

Intranasal nanoemulsion vaccine confers long‐lasting immunomodulation and sustained unresponsiveness in a murine model of milk allergy

Jessica J. O'Konek, Jeffrey J. Landers, Katarzyna W. Janczak, Hayley K. Lindsey, more

Allergy > 75 > 4 > 872 - 881

Background Immunotherapy for food allergy requires prolonged treatment protocols and, in most cases, does not lead to durable modulation of the allergic immune response. We have demonstrated an intranasal (IN) nanoemulsion adjuvant that redirects allergen‐specific Th2 responses toward Th1 and Th17 immunity, and protects from allergen challenge after only 2‐4 monthly administrations. Here, we investigate...

article

Treatment of allergic disease with nanoemulsion adjuvant vaccines

Jessica J. O’Konek, James R. Baker

Allergy > 75 > 1 > 246 - 249

article

Integrin alpha V beta 3 targeted dendrimer‐rapamycin conjugate reduces fibroblast‐mediated prostate tumor progression and metastasis

Elliott E. Hill, Jin Koo Kim, Younghun Jung, Chris K. Neeley, more

Journal of Cellular Biochemistry > 119 > 10 > 8074 - 8083

Therapeutic strategies targeting both cancer cells and associated cells in the tumor microenvironment offer significant promise in cancer therapy. We previously reported that generation 5 (G5) dendrimers conjugated with cyclic‐RGD peptides target cells expressing integrin alpha V beta 3. In this study, we report a novel dendrimer conjugate modified to deliver the mammalian target of rapamycin (mTOR)...

article

Nanoemulsion adjuvant–driven redirection of TH2 immunity inhibits allergic reactions in murine models of peanut allergy

Jessica J. O'Konek, Jeffrey J. Landers, Katarzyna W. Janczak, Rishi R. Goel, more

Journal of Allergy and Clinical Immunology > 2018 > 141 > 6 > 2121-2131

Immunotherapy for food allergies involves progressive increased exposures to food that result in desensitization to food allergens in some subjects but not tolerance to the food. Therefore new approaches to suppress allergic immunity to food are necessary. Previously, we demonstrated that intranasal immunization with a nanoemulsion (NE) adjuvant induces robust mucosal antibody and T_H17-polarized immunity,...

article

Encapsulation and release of Zafirlukast from electrospun polyisobutylene-based thermoplastic elastomeric fiber mat

Aditya Jindal, Judit E. Puskas, Andrew McClain, Kyle Nedic, more

European Polymer Journal > 2018 > 98 > C > 254-261

This paper reports the discovery that free-standing rubbery fiber mats can be electrospun from polyisobutylene-based thermoplastic elastomer/poly(ethylene glycol) mixtures from a THF-toluene solution. Direct contact and elution cytotoxic assays of these mats showed no cytotoxic response. Electrospinning the polymers mixed with Zafirlukast (ZAF), an anti-inflammatory drug, resulted in complete encapsulation...

article

Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases–Sponsored Expert Panel

Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa'ad, more

Journal of the Academy of Nutrition and Dietetics > 2017 > 117 > 5 > 788-793

article

Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel

Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa'ad, more

Annals of Allergy, Asthma & Immunology > 2017 > 118 > 2 > 166-173.e7

Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy...

article

Adjuvant-Driven Redirection of Th2 Immunity Inhibits Allergic Reactions in Murine Models of Food Allergy

Jessica J. O'Konek, Jeffrey J. Landers, Katarzyna W. Janczak, Pamela T. Wong, more

The Journal of Allergy and Clinical Immunology > 2017 > 139 > 2 Supplement > AB175

article

Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel

Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa’ad, more

Allergy, Asthma & Clinical Immunology > 2017 > 13 > 1 > 1-20

Background Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of...

article

Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel

Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa’ad, more

World Allergy Organization Journal > 2017 > 10 > 1 > 1-18

article

Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–Sponsored Expert Panel

Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa'ad, more

Pediatric Dermatology > 34 > 1 > e1 - e21

Background Food allergy is an important public health problem because it affects children and adults, can be severe and even life‐threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of...

article

Addendum guidelines for the prevention of peanut allergy in the United States

Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa'ad, more

Pediatric Dermatology > 34 > 1 > 5 - 12

article

Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–Sponsored Expert Panel

Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa'ad, more

Journal of Pediatric Nursing > 2017 > 32 > C > 91-98

article

Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel

Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa'ad, more

Journal of Allergy and Clinical Immunology > 2017 > 139 > 1 > 29-44

article

Immunomodulation of TH2 biased immunity with mucosal administration of nanoemulsion adjuvant

Anna U. Bielinska, Jessica J. O’Konek, Katarzyna W. Janczak, James R. Baker

Vaccine > 2016 > 34 > 34 > 4017-4024

T_H2-biased immune responses are associated with inadequate protection against some pathogens and with cancer, colitis, asthma and allergy. Since most currently used vaccine adjuvants induce a T_H2-biased response, this has led to interest in developing adjuvants capable of activating T_H1 immunity and modulating existing T_H2 responses. Immunotherapies to shift immune responses from T_H2 to T_H1 have generally...

chapter

Immunopathogenesis of Thyroiditis

Su He Wang, James R. Baker

Contemporary Endocrinology > Immunoendocrinology: Scientific and Clinical Aspects > Specific Diseases > 443-455

Summary Thyroiditis consists of a number of different inflammatory processes in thyroid and is caused by a variety of factors. Among the various inflammatory thyroid lesions, Hashimoto’s thyroiditis is the most common, and we will focus on the mechanisms involved in this disease. While extensive studies have been performed to elucidate the immunopathogenesis of Hashimoto’s thyroiditis, the processes...

article

Modular Integration of Upconverting Nanocrystal–Dendrimer Composites for Folate Receptor‐Specific NIR Imaging and Light‐Triggered Drug Release

Pamela T. Wong, Dexin Chen, Shengzhuang Tang, Sean Yanik, more

Small > 11 > 45 > 6078 - 6090

Upconversion nanocrystals (UCNs) display near‐infrared (NIR)‐responsive photoluminescent properties for NIR imaging and drug delivery. The development of effective strategies for UCN integration with other complementary nanostructures for targeting and drug conjugation is highly desirable. This study reports on a core/shell‐based theranostic system designed by UCN integration with a folate (FA)‐conjugated...

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INFONA - science communication portal

Search results for: James R. Baker

Recent patents in allergy and immunology: Transepidermal water loss for anaphylaxis monitoring

A Light‐Induced Decarboxylative‐Elimination of Substituted Maleimides as a Strategy Towards Triggered Photorelease

Intranasal delivery of allergen in a nanoemulsion adjuvant inhibits allergen‐specific reactions in mouse models of allergic airway disease

Intranasal nanoemulsion vaccine confers long‐lasting immunomodulation and sustained unresponsiveness in a murine model of milk allergy

Treatment of allergic disease with nanoemulsion adjuvant vaccines

Integrin alpha V beta 3 targeted dendrimer‐rapamycin conjugate reduces fibroblast‐mediated prostate tumor progression and metastasis

Nanoemulsion adjuvant–driven redirection of TH2 immunity inhibits allergic reactions in murine models of peanut allergy

Encapsulation and release of Zafirlukast from electrospun polyisobutylene-based thermoplastic elastomeric fiber mat

Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases–Sponsored Expert Panel

Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel

Adjuvant-Driven Redirection of Th2 Immunity Inhibits Allergic Reactions in Murine Models of Food Allergy

Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel

Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel

Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–Sponsored Expert Panel

Addendum guidelines for the prevention of peanut allergy in the United States

Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–Sponsored Expert Panel

Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel

Immunomodulation of TH2 biased immunity with mucosal administration of nanoemulsion adjuvant

Immunopathogenesis of Thyroiditis

Modular Integration of Upconverting Nanocrystal–Dendrimer Composites for Folate Receptor‐Specific NIR Imaging and Light‐Triggered Drug Release

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