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Background
The antifibrinolytic drug tranexamic acid (TXA) improves survival in adults with traumatic hemorrhage; however, the drug has not been evaluated in a trial in injured children. We assessed the feasibility of a large‐scale trial evaluating the effects of TXA in children with severe hemorrhagic injuries.
Methods
Severely injured children (0 up to 18th birthday) were randomized into a double‐blind...
Aim
To test the potential benefit of extending cognitive–behavioral therapy (CBT) relative to not extending CBT on long‐term abstinence from smoking.
Design
Two‐group parallel randomized controlled trial. Patients were randomized to receive non‐extended CBT (n = 111) or extended CBT (n = 112) following a 26‐week open‐label treatment.
Setting
Community clinic in the United States.
Participants...
In animal models and human studies, traumatic brain injury (TBI) is known to be associated with a secondary injury that occurs after the initial impact. There is a growing body of evidence in laboratory and clinical studies that moderate hypothermia may have a beneficial effect on attenuating cerebral tissue damage. Further studies are necessary to ensure safety and efficacy of hypothermia in the...
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